The work programme consists of six projects that strive for our vision from different perspectives, organised in three themes: Data & Methods (D), Models & Interpretation (M), and Inference & Causality (C). Project D1 will advance deep learning strategies to explore and process long-term temporal changes based on the integration of multi-dimensional and multi-source data. Project D2 will combine neural networks and mixed effects models to predict individual health trajectories over the life-course. Project M1 will advance normalizing flow methods to derive joint distributions and conditional densities for health outcomes. Project M2 will create a cognitive digital twin from human everyday activities to predict changes across age groups and to simulate data for rare conditions. Project C1 will develop explainable AI methods for recurrent neural networks and time-to-event outcomes that are able to learn and adapt over time. Project C2 will establish a causal discovery framework for lifespan studies by combining datasets with age or time overlap and allowing for nonlinearities.The research unit draws expertise from applicants of both universities in Bremen and the Leibniz Institute for Prevention Research and Epidemiology – BIPS, who jointly cover disciplines ranging from mathematics and computer science to statistics and epidemiology. All applicants are located in Bremen and are already connected via institutional links, high-profile areas, joint centres, and various initiatives. This research unit is further strengthened by the newly established cooperation professorship on “Machine Learning in Statistics” at the interface between AI and epidemiology, which serves as the bridge professorship.